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The MPN-RC Structure

Thirteen different institutions are currently participating in the MPN-RC. Each institution has its own unique intellectual environment, clinical and research facilities.

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Discovery Science

Project 1

Molecular Pathogenesis and Therapy of Myeloproliferative Neoplasms

Discovery Science

Project 2

Defining the Role of Megakaryocyte Abnormalties in the Progression of Primary Myelofibrosis

Cores

Cores

Core A: Administrative Core Core B: Tissue Bank Core Core C: Biostatistics and Data Management Core Core D: Biomarker and Bioinformatics Core

Discovery Science

Project 3

Development of Strategies to Deplete Myelofibrosis Stem Cells

Discovery Science

Project 4

MPN-RC Clinical Consortium

Arrow Project 3

Project 4

Project 4: MPN-RC Clinical Consortium

Principal Investigator: John Mascarenhas (PI), MD Ruben Mesa (co-PI), MD

“The MPN Clinical Consortium” is the clinical hub of the MPN-RC and is directed by Drs. John Mascarenhas and Ruben Mesa. They will pursue a series of hypothesis testing clinical trials which will each be directed toward depleting or eliminating MPN HSCs and/or inhibiting aberrant inflammatory signaling supporting this malignant HSC population. They will focus on mechanism-based early phase (I/II) clinical trials that emanate from the laboratory projects and which test and credential novel single and combination therapeutic approaches based on biological insights.

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