Project 4: MPN-RC Clinical Consortium
Principal Investigator: John Mascarenhas (PI), MD Ruben Mesa (co-PI), MD
“The MPN Clinical Consortium” is the clinical hub of the MPN-RC and is directed by Drs. John Mascarenhas and Ruben Mesa. They will pursue a series of hypothesis testing clinical trials which will each be directed toward depleting or eliminating MPN HSCs and/or inhibiting aberrant inflammatory signaling supporting this malignant HSC population. They will focus on mechanism-based early phase (I/II) clinical trials that emanate from the laboratory projects and which test and credential novel single and combination therapeutic approaches based on biological insights.