Who we are

Introducing the MPN-RC Team working on a mission to cure Myelofibrosis.



(Myeloproliferative Neoplasms Research Consortium)

The Myeloproliferative Neoplasms Research Consortium (MPN-RC) is an inter-active group of laboratory scientists, clinical scientists, and a biostatistics team, who work in coordination to develop and evaluate treatments that will improve the survival of patients with myeloproliferative neoplasms (MPN). The overall goal of the MPN-RC is to merge the skills and efforts of its scientifically diverse membership to generate the scientific foundation for novel therapeutic strategies which will be evaluated in rigorous, well- constructed independent investigator-initiated clinical trials.  The MPN-RC, formerly MPD-RC, opened its first trial over a decade ago. Investigators from over 30 institutions in the US, Canada, Europe, and Israel had treated over 300 patients diagnosed with myelofibrosis, polycythemia vera, thrombocythemia, and acute myeloid leukemia. Currently, the MPN-RC has investigators in 11 institutions around the US and in Canada.

The MPN-RC Projects

The MPN-RC program has eight major projects.

The program, developed with the efforts of all the members of the Consortium, consists of basic, translational and clinical studies. All of the projects are considered highly meritorious, very strong in preliminary data and research design, and with great potential to produce significant results.

Project Leaders

Project 1

Molecular Pathogenesis and Therapy of Myeloproliferative Neoplasms

View Project Details

Ross Levine, PhD

Project 2

Defining the Role of Megakaryocyte Abnormalties in the Progression of Primary Myelofibrosis

View Project Details

John Crispino (PI), PhD

Annarita Migliaccio (co-PI), PhD

Project 3

Development of Strategies to Deplete Myelofibrosis Stem Cells

View Project Details

Ronald Hoffman, MD

Project 4

MPN-RC Clinical Consortium

View Project Details

John Mascarenhas (PI), MD

Ruben Mesa (co-PI), MD

Core Leaders

Core A

Administrative Core

Ronald Hoffman, MD

Core B

Tissue Bank Core

Rona Weinberg, PhD

Core C

Biostatistics and Data Management Core

Amylou Dueck, PhD

Core D

Biomarker and Bioinformatics Core

Raajit Rampal, MD, PhD

Clinical Research Sites

Mount Sinai

John Mascarenhas
[email protected]

Mayo Clinic Arizona

Jeanne Palmer
[email protected]

Cleveland Clinic Lerner College of Medicine of CWRU

Aaron Gerds
[email protected]

H. Lee Moffitt Cancer Center and Research Institute, Inc.

Rami Komrokji
[email protected]

Sloan Kettering Institute for Cancer Research

Raajit Rampal
[email protected]

The Regents of the University of Michigan

Moshe Talpaz
[email protected]

University Health Network

Vikas Gupta
[email protected]

University of Kansas Medical Center

Abdulraheem Yacoub
[email protected]

Wake Forest University Health Sciences

Rupali Bhave
[email protected]

UT Health San Antonio

Ruben Mesa
[email protected]

Cedars Sinai Medical Center

Ronald Paquette
[email protected]

Want to learn more about our studies?

Take a look at our projects with more detailed descriptions of our structure and process.